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GSH deficiency as evidenced by a decrease in the GSH/GSSG ratio manifests itself largely through an increased susceptibility to oxidative stress, and the resulting damage is thought to be involved in SARS-CoV-2 infection leading to COVID-19 disease (6, 7, 39, 4353)

However, their biological activity has been evaluated in only a limited number of cell lines and primarily through single metabolic assays, which limits the ability to draw clear conclusions about their mechanism of action and therapeutic potential

Distant effects of experimental renal ischemia/reperfusion injury

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On this occasion, the authors expand our understanding of glutathione biology and identify extracellular glutathione (GSH), abundant in the tumour microenvironment, as an alternative source of essential amino acids to sustain tumour cell proliferation

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