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Utilization of site-directed spin labeling and high-resolution heteronuclear nuclear magnetic resonance for global fold determination of large proteins with limited nuclear overhauser effect data

No human dose-response data exists

Animal study ranges In rodent models, PE-22-28 has typically been administered in very small doses, often in the microgram per kilogram (g/kg) range

The 4-week minimum at each phase exists because some side effects have delayed onset

no human validation Approach Published mouse regimen Pattern 5 mg/kg IP, ~3x/week Duration Several weeks Notes Animal only

Endocr Rev 28(1):84116 Gu W, Winters KA, Motani AS, Komorowski R, Zhang Y, Liu Q et al (2010) Glucagon receptor antagonist-mediated improvements in glycemic control are dependent on functional pancreatic GLP-1 receptor