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FIGURE 5 NO binds to CIV at both normoxic oxygen concentrations, where CIV is primarily oxidized, and hypoxic oxygen concentrations, where CIV is primarily reduced

Nonetheless, studies conducted in living organisms indicate that their concentrations are often insufficient to effectively traverse the bloodbrain barrier, limiting their bioavailability, stability, and dissolution at the intended brain sites

10.1159/000331717 56 ZhangL.HuangB.ScherlagB

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For charge state z = 2, the MS isolation window was set at 1.2