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Foundational NNMT Discoveries The foundational research establishing NNMT as a metabolic regulator and potential therapeutic target came from studies by Daniel Kraus and colleagues published in Nature in 2014, which demonstrated that NNMT expression is dramatically upregulated in adipose tissue of obese humans and diet-induced obese mice, and that genetic knockdown of NNMT in mice protected against diet-induced obesity and improved metabolic parameters

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Similarly, the study found that fragment 176-191, both alone and in combination with HA, reduces disability associated with osteoarthritis

An investor briefing on Calzada's prospects was arranged for Essendon president David Evans, who heads an investment firm, and coach James Hird in early 2012 by Mr Dank