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On the other hand, topical GHK-Cu is recognized as a safe peptide to use topically, with clinical studies demonstrating its support of skin health and tested specifically as ways to improve aging skin

Copper is involved in many biological processes, which is one reason GHK-Cu has become widely discussed in research

Gastrointestinal symptoms, primarily nausea, vomiting, and diarrhea, are most common during the dose escalation phase and typically improve after 4 to 8 weeks at a stable dose

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The peptide was originally characterized by the Sikiric group at the University of Zagreb School of Medicine and has been investigated for over two decades in preclinical research models for its effects on tissue regeneration, angiogenesis, fibroblast migration, and cellular signaling across tendon, ligament, muscle, gastrointestinal, and vascular tissues