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Cell culture studies have shown that phenobarbital (PB), phenytoin (PHT), primidone (PRM), carbamazepine (CBZ), oxcarbazepine and felbamate induce CYP3A4 expression, whereas ethosuximide (ETHS), valproic acid (VPA), and lamotrigine (LTG) have no effect on CYP3A4 activity 60, 61

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In this regards, SODs are classified into three forms and these include (i) Fe-SOD which is commonly found in prokaryotes and chloroplasts of some plants (ii) Mn-SOD which is present in prokaryotes and mitochondria of eukaryotes and (iii) Cu/Zn-SOD is predominant in eukaryotes and more distributed, localized basically in cytosol but also found in chloroplasts and peroxisomes.25, 26 The various isozymes of SOD are encoded by different genes

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Biological role of TST in mitochondrial processes Mitochondria, often referred to as the powerhouse of the cell, exhibit remarkable plasticity and dynamism, enabling cells to adapt and respond to various environmental stressors and metabolic demands [1]