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This work highlights enzymatic production is inducible and robust in select tissues, whereas iron-catalyzed production contributes underappreciated basal H 2 S systemically with pathophysiological implications in hemolytic, iron overload, and hemorrhagic disorders

Additionally, p53 silencing did not cause any change in cell viability upon cisplatin treatment

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Aggregation of these disrupts normal cellular processes, such as protein degradation, resulting in cellular stress and, ultimately, cell death (Tsoi et al., 2023)