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In sporadic PD patients, the degree and prevalence of Complex I deficiency are heterogeneous

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Additionally, hypermethylation of the Foxp3 gene promoter in T cells results in reduced Foxp3 expression, impairing Treg cell function and disrupting immune homeostasis, thereby exacerbating MS progression (83, 85)

For the result of PCD prevalence estimation by the Bayesian framework in other gnomAD populations, the prevalence is 1:1,134,461 (95% confidence interval: 1:2,300,3251:650,711) in African American (AFR) population, 1:148,320 (95% confidence interval: 1:314,1551:82,852) in admixed American (AMR) population, 1:921,025 (95% confidence interval: 1:28,837,5931:211,888) in ASJ population, 1:1,964,440 (95% confidence interval: 1:13,880,6671:645,273) in Finnish in Finland (FIN) population, 1:282,613 (95% confidence interval: 1:413,7091:202,688) in NFE population, 1:84,707 (95% confidence interval: 1:404,3291:31,975) in South Asian (SAS) population, and 1:16,375 (95% confidence interval: 1:41,4101:8,272) in East Asian (EAS) population (Figure 3B)

parkeri fitness, pathogenesis and innate immune evasion are unclear