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Walker Alan R

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The compartments are : The intestine that absorbs the rapamycin and send it into the blood The blood is the central compartment that gets the rapamycin from the intestine and has bidirectional exchanges with the organs as well as some elimination (by metabolization) The organs which exchange Rapamycin with the blood (both ways) Here is that model with the differential equations fitted to the paper data for rapamycin + fat (dots) [image] As you can see the fit is very good which shows that the 3 compartment model is good enough

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We'll assess whether your levels are moving toward optimal ranges and adjust dosing if needed

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