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The cut-off point for cotinine in plasma or saliva is 10ng/ml, and in urine is 200ng/ml.31 The Fagerstrm test and Heaviness of Smoking Index have been shown to be useful in these patients for diagnosing the degree of physical dependence on nicotine.23,24 Nevertheless, it is important to highlight that in this group of smokers, suffering from this chronic respiratory condition does not allow them to smoke a large number of cigarettes per day