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Functional HIF-1 corresponding elements were found in the promoter sequence of the human BNP gene, proving that HIF-1 can induce the activation of the BNP promoter, the transcription of BNP mRNA, and the synthesis and secretion of BNP under hypoxic conditions [90]

The restrictive properties of the BBB as a physical barrier are characterized by the lack of fenestrations and the presence of tight junctions (TJ) between the brain capillary endothelial cells (8, 9)